Table 1.

Activity of Heat Shock Protein 90 Inhibitors Against Trypanosomes In Vitro

Compound	EC50 (nM)a
Geldanamycin	12 ± 4
Radicicol	70 ± 14
Novobiocin	180 000 ± 21 000

Abbreviation: EC₅₀, half maximal effective concentration

^a Values are mean ± SD of at least 3 independent experiments. r² values for dose-response curves all exceeded 0.99; within an assay, the coefficients of variation for quadruplicate determinations were all ≤10% and averaged 1.8%.