Table 1.

Experimental Scheme for the Addition of Phosphodiesterase Inhibitors to the Standard Tuberculosis Treatment Regimen

	Mice Euthanized, No., by Time Point
Regimen	D–13	D0	Mo1	Mo2	Mo3	Mo4	Mo5	Mo6	Mo 4 + 3a	Mo 5 + 3b	Mo 6 + 3c
Untreated	5	5	…	…	…	…	…	…	…	…	…
Standard (2RHZ/4RH)	…	…	5	5	5	5	5	5	10	10	10
Standard + rolipram	…	…	5	5	5	5	5	5	10	10	10
Standard + cilostazol/sildenafil	…	…	5	5	5	5	5	5	10	10	10
Total	5	5	15	15	15	15	15	15	30	30	30

Abbreviations: H, isoniazid; R, rifampin; Z, pyrazinamide.

^a Treatment was stopped after 4 months, and mice were euthanized 3 months later to assess relapse.

^b Treatment was stopped after 5 months, and mice were euthanized 3 months later to assess relapse.

^c Mice were euthanized 3 months after the full treatment course to assess relapse.