Figure 1.

Characteristics of simian/human immunodeficiency virus (SHIV) 162P3_K65R in vitro. A, Susceptibility of SHIV162P3_K65R to tenofovir (TFV) and emtricitabine (FTC). Values denote the inhibition of the percentage of protection seen in TZM-bl cells at increasing concentrations of drug. Data represent 2 separate experiments done in triplicate. B, Competition dynamics among wild-type (WT) SHIV162P3 and SHIV162P3_K65R. The experiment was initiated at an 80:20 mutant to WT ratio. The two lines denote the proportion of K65R and WT SHIV, over time.