Table 3.
Comparison of ICSI responder rates between chondroitin sulphate and control groups at end of treatment period and end of study
| Study | End of treatment | End of study | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Chondroitin sulphate | Control | RR | Chondroitin sulphate | Control | RR | |||||||||
|
| ||||||||||||||
| n | R | Rate | n | R | Rate | (95% CI) | n | R | Rate | n | R | Rate (%) | (95% CI) | |
| RCT 1 | 33 | 12 | 36.4% | 31 | 7 | 22.6% | 1.66 (0.73, 3.55) | 29 | 12 | 41.4% | 30 | 10 | 33.3% | 1.24 (0.63, 2.42) |
| RCT 2 | 50 | 23 | 46% | 48 | 18 | 37.5% | 1.23 (0.76, 1.97) | 44 | 19 | 43.2% | 44 | 17 | 38.6% | 1.12 (0.68, 1.85) |
| OLS | 53 | 31 | 59.6% | – | – | – | - | 50 | 29 | 58.0% | – | – | – | – |
| Pooled (95% CI) | 48.0% (34.9, 61.0) | 30.3% (15.7, 44.9) | 1.54 (1.04, 2.30)* | 48.4% (37.7, 59.1) | 36.4% (34.3, 41.5) | 1.34 (1.03, 1.73)** | ||||||||
*
p = 0.033;
**
p = 0.028; ICSI: Interstitial Cystitis Symptom Index; R: response; CI: confidence interval; RR: risk ratio; RCT: randomized control trial; OLS: open-label study.