Table 5.
Comparison of ICPI responder rates between chondroitin sulphate and control groups at end of treatment period and end of study
| Study | End of treatment | End of study | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Chondroitin sulphate | Control | RR | Chondroitin sulphate | Control | RR | |||||||||
|
| ||||||||||||||
| n | R | Rate | n | R | Rate | (95% CI) | n | R | Rate | n | R | Rate (%) | (95% CI) | |
| RCT 1 | 33 | 14 | 42.4% | 31 | 13 | 41.9% | 1.01 (0.57, 1.80) | 29 | 11 | 37.9% | 30 | 9 | 30.0 | 1.26 (0.62, 2.59) |
| RCT 2 | 50 | 28 | 56.0% | 48 | 20 | 41.7% | 1.34 (0.89, 2.04) | 44 | 18 | 40.9% | 43 | 21 | 48.8 | 0.84 (0.52, 1.33) |
| OLS | 51 | 26 | 50.0% | – | – | – | 50 | 29 | 58.0% | – | – | – | ||
| Pooled (95% CI) | 50.7% (42.3, 59.1) | 41.8% (30.9, 52.6) | 1.21 (1.06, 1.40)* | 46.3% (33.7, 59.0) | 39.7 (21.3, 58.2) | 1.15 (0.72, 1.83)** | ||||||||
*
p = 0.006;
**
p = 0.565; ICPI: Interstitial Cystitis Problem Index; RR: risk ratio; R: response; CI: confidence interval; RCT: randomized control trial; OLS: open-label study.