Table 1.
Composition, physiochemical properties, and permeability parameters of citalopram-loaded model microemulsions
| X1 | X2 | X3 | Size (nm) | PI | Viscosity (cps × 103) | Flux(μg/cm2/h) | LT (h) | |
|---|---|---|---|---|---|---|---|---|
| F01 | 23.3 | 23.3 | 43.3 | 13.9 ± 0.7 | 0.39 ± 0.18 | 10.23 ± 0.06 | 163.8 ± 4.5 | 1.3 ± 0.6 |
| F02 | 21.7 | 26.7 | 41.7 | 16.0 ± 2.0 | 0.38 ± 0.13 | 8.9 ± 0.07 | 161.5 ± 6.8 | 1.0 ± 0.0 |
| F03 | 20.0 | 30.0 | 40.0 | 16.5 ± 0.1 | 0.47 ± 0.04 | 7.53 ± 0.06 | 165.0 ± 20.7 | 0.8 ± 0.3 |
| F04 | 25.0 | 25.0 | 40.0 | 38.0 ± 10.5 | 0.43 ± 0.10 | 9.80 ± 0.10 | 172.1 ± 14.1 | 2.0 ± 0.0 |
| F05 | 20.0 | 20.0 | 50.0 | 19.9 ± 3.7 | 0.30 ± 0.15 | 10.73 ± 0.12 | 153.8 ± 16.1 | 1.2 ± 0.8 |
| F06 | 20.0 | 30.0 | 40.0 | 17.3 ± 2.4 | 0.43 ± 0.12 | 7.08 ± 0.07 | 179.8 ± 11.8 | 1.5 ± 0.9 |
| F07 | 20.0 | 20.0 | 50.0 | 17.7 ± 3.2 | 0.33 ± 0.18 | 10.17 ± 0.06 | 179.8 ± 18.1 | 1.7 ± 0.6 |
| F08 | 25.0 | 25.0 | 40.0 | 20.8 ± 6.4 | 0.36 ± 0.09 | 9.22 ± 0.04 | 176.8 ± 15.9 | 1.7 ± 0.6 |
| F09 | 30.0 | 20.0 | 40.0 | 18.5 ± 10.7 | 0.44 ± 0.10 | 13.07 ± 0.06 | 191.8 ± 14.6 | 2.7 ± 0.6 |
| F10 | 21.7 | 21.7 | 46.7 | 14.5 ± 0.5 | 0.33 ± 0.01 | 10.23 ± 0.06 | 188.6 ± 13.4 | 2.3 ± 0.6 |
| F11 | 30.0 | 20.0 | 40.0 | 32.1 ± 5.5 | 0.34 ± 0.05 | 12.70 ± 0.00 | 216.1 ± 11.0 | 2.7 ± 0.6 |
| F12 | 25.0 | 20.0 | 45.0 | 13.5 ± 0.2 | 0.45 ± 0.09 | 12.00 ± 0.10 | 211.0 ± 8.1 | 3.0 ± 0.0 |
| F13 | 26.7 | 21.7 | 41.7 | 13.2 ± 0.1 | 0.45 ± 0.09 | 11.30 ± 0.10 | 221.5 ± 8.9 | 2.7 ± 0.6 |
| F14 | 20.0 | 25.0 | 45.0 | 13.2 ± 0.1 | 0.36 ± 0.14 | 9.52 ± 0.10 | 245.6 ± 14.0 | 2.7 ± 0.6 |
Notes: Amount of citalopram and isopropyl myristate was fixed at 300 mg and 1.0 g, respectively; total amount of three variables of X1 (Brij 30/Brij 35 = 4/1, 20%–30%), X2 (isopropyl alcohol 20%–30%), and X3 (distilled water, 40%–50%) was 9.0 g X1 + X2 + X3 = 1.
Abbreviations: LT, lag time; PI, polydispersity index.