Table III.
Risk of Breast Cancer by HT & BRCA1 Genotypes among White WEB Study Participants
| Cases | Controls | Crude OR (95% CI) | Adjusted OR1 (95% CI) | |
|---|---|---|---|---|
| Q356R (rs1799950) | ||||
| Post-menopausal2 | ||||
| Never HRT + TT | 279 | 490 | 1.00 | 1.00 |
| Never HRT + CT&CC | 33 | 77 | 0.75 (0.49–1.16) | 0.75 (0.49–1.16) |
| HRT + TT | 345 | 533 | 1.14 (0.93–1.39) | 1.18 (0.97–1.45) |
| HRT + CT&CC | 47 | 85 | 0.97 (0.66–1.43) | 1.01 (0.68–1.49) |
| P for interaction | 0.67 | 0.68 | ||
|
| ||||
| D693N (rs4986850) | ||||
| Post-menopausal3 | ||||
| Never HRT + CC | 285 | 474 | 1.00 | 1.00 |
| Never HRT + CT&TT | 32 | 93 | 0.57 (0.37–0.88) | 0.57 (0.37–0.87) |
| HRT + CC | 335 | 535 | 1.04 (0.85–1.27) | 1.09 (0.89–1.34) |
| HRT + CT&TT | 58 | 80 | 1.21 (0.83–1.74) | 1.27 (0.87–1.84) |
| P for interaction | 0.01 | 0.01 | ||
|
| ||||
| E1038G (rs16941) | ||||
| Post-menopausal4 | ||||
| Never HRT + TT | 145 | 244 | 1.00 | 1.00 |
| Never HRT + CT | 137 | 243 | 0.95 (0.71–1.27) | 0.95 (0.71–1.27) |
| Never HRT + CC | 29 | 77 | 0.63 (0.40–1.02) | 0.63 (0.39–1.02) |
| HRT + TT | 171 | 280 | 1.03 (0.78–1.36) | 1.07 (0.81–1.42) |
| HRT + CT | 166 | 279 | 1.00 (0.76–1.33) | 1.04 (0.78–1.38) |
| HRT + CC | 53 | 52 | 1.72 (1.11–2.65) | 1.79 (1.16–2.78) |
| P for interaction | 0.02 | 0.02 | ||
1
Odds ratios and 95% confidence intervals adjusted for age.
2
N=704 and 1185 for cases and controls, respectively
3
N=710 and 1182 for cases and controls, respectively
4
N=701 and 1175 for cases and controls, respectively