Table IV.
Risk of Breast Cancer by BMI & BRCA1 Genotypes, among Whites, WEB Study
| Cases | Controls | Crude OR (CI) | Adjusted OR1 (CI) | |
|---|---|---|---|---|
| E1038G (rs16941) | ||||
| Pre-menopausal2 | ||||
| ≤30 BMI + TT | 89 | 179 | 1.00 | 1.00 |
| ≤30 BMI + CT | 93 | 169 | 1.11 (0.77–1.58) | 1.12 (0.78–1.60) |
| ≤30 BMI + CC | 12 | 37 | 0.65 (0.32–1.31) | 0.67 (0.33–1.36) |
| >30 BMI + TT | 32 | 76 | 0.85 (0.52–1.38) | 0.84 (0.51–1.36) |
| >30 BMI + CT | 32 | 59 | 1.09 (0.66–1.80) | 1.06 (0.64–1.75) |
| >30 BMI + CC | 10 | 6 | 3.35 (1.18–9.52) | 3.19 (1.12–9.09) |
| P for interaction | 0.03 | 0.045 | ||
| Post-menopausal3 | ||||
| ≤30 BMI + TT | 208 | 374 | 1.00 | 1.00 |
| ≤30 BMI + CT | 200 | 381 | 0.94 (0.74–1.20) | 0.94 (0.74–1.20) |
| ≤30 BMI + CC | 45 | 86 | 0.94 (0.63–1.40) | 0.95 (0.63–1.41) |
| >30 BMI + TT | 112 | 167 | 1.21 (0.90–1.62) | 1.21 (0.90–1.62) |
| >30 BMI + CT | 103 | 158 | 1.17 (0.87–1.58) | 1.17 (0.87–1.59) |
| >30 BMI + CC | 38 | 45 | 1.52 (0.96–2.42) | 1.51 (0.95–2.40) |
| P for interaction | 0.43 | 0.44 | ||
1
Odds ratios and 95% confidence intervals adjusted for age (the matching variable).
2
N=268 and 526 for cases and controls, respectively
3
N=706 and 1211 for cases and controls, respectively