Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Genet Epidemiol. 2013 May 14;37(5):504–511. doi: 10.1002/gepi.21730

Table V.

Risk of Molecular Breast Cancer Subtype by BRCA1 Genotypes among White WEB Study Participants (Triple negative vs. other subtypes)

BRCA1 genotypes Other Subtypes1 Triple Negative2 Crude OR (95% CI) Adjusted OR3 (95% CI)
Q356R (rs1799950)4
1: TT 469 95 1.00 1.00
2: CT+CC 68 12 1.15 (0.60–2.20) 1.15 (0.60–2.22)
D693N (rs4986850)5
1: CC 456 98 1.00 1.00
2: CT+TT 84 8 2.26 (1.06–4.81) 2.31 (1.08–4.93)
E1038G (rs16941)6
1: TT 236 53 1.00 1.00
2: CT 229 43 1.20 (0.77–1.86) 1.20 (0.77–1.87)
3: CC 65 8 1.83 (0.83–4.03) 1.79 (0.81–3.97)
1

Other Subtypes includes: Luminal A: ER+ or PR+, HER2-; Luminal B: ER+ or PR+, HER2+; HER2 Expressing: ER−/PR−, HER2+

2

Triple-negative: ER−/PR−/HER2−

3

Odds ratios and 95% confidence intervals adjusted for age (the matching variable).

4

N=537 and 107 for cases and controls, respectively

5

N=540 and 106 for cases and controls, respectively

6

N=530 and 104 for cases and controls, respectively