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. Author manuscript; available in PMC: 2013 Jul 2.
Published in final edited form as: Arthritis Rheum. 2011 May;63(5):1237–1245. doi: 10.1002/art.30164

Figure 3.

Figure 3

High frequency of HEp-2 reactive mature naïve B cells from RA patients after methotrexate and anti-TNFα treatment. Antibodies from mature naïve B cells from healthy donors (A) and RA patients before and after treatment with methotrexate (B), and before and after anti-TNFα therapy (C) were tested by ELISA for anti-HEp-2 cell reactivity. Dotted lines show ED38 positive control. Horizontal lines show cut-off OD405 for positive reactivity. The frequency of HEp-2-reactive and non HEp-2-reactive clones is summarized in pie charts with the number of antibodies tested indicated in the centers.