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. Author manuscript; available in PMC: 2013 Jul 2.
Published in final edited form as: Arthritis Rheum. 2011 May;63(5):1237–1245. doi: 10.1002/art.30164

Figure 4.

Figure 4

Mature naïve B cells from RA patients after methotrexate or anti-TNFα treatments express polyreactive antibodies. Antibodies from mature naïve B cells from RA patients after methotrexate and anti-TNFα treatment were tested by ELISA for reactivity with single-stranded DNA (ss-DNA), double-stranded DNA (ds-DNA), insulin and lipopolysaccharide (LPS). Dotted lines show ED38 positive control. Horizontal lines shoe cut-off OD405 for positive reactivity. For each individual, the frequency of polyreactive (in black) and non polyreactive (in white) clones is summarized in pie-charts with the number of antibodies tested indicated in the centers.