. Author manuscript; available in PMC: 2013 Jul 2.

Published in final edited form as: J Thromb Thrombolysis. 2011 May;31(4):514–522. doi: 10.1007/s11239-011-0574-9

Table 3.

Incidence rates of untoward events according to INR in patients with mechanical heart valves

INR	All events, incidence^a (95% CI)	Life-threatening and fatal events, incidence^a (95% CI)
< 2	31.9 (5.7, 79.4)	10.6 (0.0, 42.6)
2.0–2.4	6.7 (0.6, 19.4)	3.3 (0.0, 13.3)
2.5–2.9	2.0 (0.2, 5.7)	1.0 (0.1, 4.4)
3.0–3.9	2.5 (1.3, 4.0)	1.1 (0.4, 2.1)
4.0–4.9	3.3 (1.6, 5.5)	1.8 (0.6, 3.5)
≥5.0	24.7 (13.3, 39.7)	5.3 (0.9, 13.2)

CI indicates confidence interval, INR international normalized ratio.

Per 100 patient-years. Adapted from Arch Intern Med 2009;169: 1203–1209 [22]