Table 5.
Short-QT syndrome (SQTS)
| Name | Current | Gain/loss of function | Protein | Gene | Reference |
|---|---|---|---|---|---|
| SQT1 | IKr | Gain | Kv11.1 | KCNH2 | Brugada et al112 |
| SQT2 | IKs | Gain | KvLQT1 | KCNQ1 | Bellocq et al113 |
| SQT3 | IK1 | Gain | Kir2.1 | KCNJ2 | Priori et al114 |
| SQT4 | ICa,L | Loss | Cav1.2α1 | CACNA1C | Antzelevitch et al58 |
| SQT5 | ICa,L | Loss | Cavβ2b | CACNB2b | Antzelevitch et al58 |
| SQT6 | ICa,L | Loss | Cavα2δ-1 | CACNA2D1 | Templin et al115 |
Abbreviations: IKr and IKs, rapid and slow delayed-rectifier potassium currents, respectively; IK1, inward-rectifier potassium current; ICa, L, L-type calcium current.