Figure 2.
CAESM-induced fluorescein staining results in multiple regions of the eye, in patients with a history of dry eye and objective evidence of ongoing dry eye disease, after 28 days of treatment with a novel TrkA agonist (MIM-D3).
Notes: The data are reported as the change from pre- to post-CAE. Treatment with 1% MIM-D3 showed significant (*P < 0.05 or **P < 0.01 from a two-sample t-test) improvement compared with placebo in multiple regions, at day 28. Corneal sum refers to the sum of scores of the inferior, central, and superior regions. Conjunctival sum refers to the sum of scores of the nasal and temporal regions.
Abbreviations: CAE, Controlled Adverse Environment; SE, standard error; TrkA, receptor tyrosine kinase-A.