Figure 3.

Mean fluorescein and lissamine staining scores in the inferior cornea after challenge in the CAE^SM, in patients with a history of dry eye and objective evidence of ongoing dry eye disease, after 28 days of treatment with a novel TrkA agonist (MIM-D3). Treatment with 1% MIM-D3 showed significant (*P < 0.05 or **P < 0.01 from a two-sample t-test) improvement compared with placebo as early as day 14. (A) Mean fluorescein staining scores measured post-CAE; (B) mean CAE-induced fluorescein staining reported as the change from pre- to post-CAE; (C) mean lissamine green staining scores measured post-CAE; and (D) mean CAE-induced lissamine green staining reported as the change from pre- to post-CAE.

Abbreviations: CAE, controlled Adverse Environment; SE, standard error; TrkA, receptor tyrosine kinase-A.