Table 2.

Parameters of our model, and their physical equivalents.

Simulation parameter	Value	Physical equivalent	Value
PA(BA)	101–106 ‡	KA BCR-antigen	105–1010 M−1 [7,8]
pon(BA)	0.1‡	kon BCR-antigen	106 M−1s−1 [7,8]
poff(BA)	10−2–10−7 ‡	koff BCR-antigen	101–10−4 s−1 [7,8]
B0	400 molecules	BCR molecules/cell	~105 [37]
A0	200 molecules ‡	Antigen conc.	100 molec./μm2 [7]
L0	100 molecules †‡	Lyn molecules/cell	2×104
S0	400 molecules †‡	Syk molecules/cell	4×105
pdiff(F)	1	Dfree molecules	0.1 μm2/s [35]
pdiff(C)	0.1	Dcomplexes	~0.01 μm2/s [22]
pon(olig)	0.1‡	kon(BCR-BCR)	100 molec−1s−1
PA(Lyn)	102 †‡	KA Ig-α/β-Lyn	106 M−1
pon(Lyn)	1.0 †‡	kon Ig-α/β-Lyn	~107 M−1 s−1
poff(Lyn)	0.01 †‡	koff Ig-α/β-Lyn	~10 s−1
pon(Syk)high	1.0 †‡	kon Ig-α/β-Syk	~107 M−1 s−1
pon(Syk)low	0.1 †‡	kon Ig-α/β-Syk	~106 M−1 s−1
poff(Syk)high	1.0 †‡	koff Ig-α/β-Syk	~1000 s−1
poff(Syk)low	0.001 †‡	koff Ig-α/β-Syk	~1 s−1
pphos(Lyn)	0.1 †‡	kphos(Lyn)	~100 s−1
pphos(Syk)high	1.0 †‡	kphos(Syk)high	~1000 s−1
pphos(Syk)low	0.5 †‡	kphos(Syk)low	~500 s−1
pSyk(phos)	1.0 †‡	kSyk(phos)	~1000 s−1
pphos(SykSyk)	0.01†‡	kphos(SykSyk)	~10 s−1

^†Represents a ballpark value calculated from [38,39]

^‡Parametric study performed