Table 3.
Numbers of referrals (denominator) made by each tool at different cutoffs and the number of carriers (numerator) out of those referrals. The bold numbers correspond to the commonly used threshold of 10% for referral by BRCAPRO and for simpler tools, they correspond to the modified thresholds at which the respective tools perform closest to BRCAPRO. LYTE represents BRCAPROLYTE.
| Cutoff | BRCAPRO | LYTE | LYTE-Plus | BRCAPRO-1Degree | LYTE-Simple | FHAT |
|---|---|---|---|---|---|---|
| 0.3 | 300/580 = 0.52 | 387/997 = 0.39 | 276/527 = 0.52 | 307/713 = 0.43 | 316/648 = 0.49 | |
| 0.25 | 320/649 = 0.49 | 407/1105 = 0.37 | 298/590 = 0.51 | 329/815 = 0.40 | 334/721 = 0.46 | |
| 0.2 | 345/734 = 0.47 | 436/1250 = 0.35 | 319/652 = 0.49 | 352/922 = 0.38 | 357/818 = 0.44 | |
| 0.1 | 413/1031 = 0.40 | 493/1631 = 0.30 | 379/902 = 0.42 | 418/1301 = 0.32 | 426/1166 = 0.37 | |
| 0.05 | 457/1358 = 0.34 | 531/2027 = 0.26 | 438/1243 = 0.35 | 475/1726 = 0.28 | 486/1521 = 0.32 | |
| 0.03 | 497/1620 = 0.31 | 552/2254 = 0.24 | 471/1476 = 0.32 | 516/2060 = 0.25 | 511/1788 = 0.29 | |
| 0.01 | 547/2069 = 0.26 | 568/2583 = 0.22 | 535/2002 = 0.27 | 560/2542 = 0.22 | 556/2299 = 0.24 | |
| 10 | 488/1625 = 0.30 |