Table 4.
NRI statistic and its four components representing the proportions of carriers (C) and non-carriers (NC) who got reclassified as high risk (moved up) or low risk (moved down) when a simplified tool is used in place of BRCAPRO at the same cutoff. So, the four components are C.up, C.down, NC.up, and NC.down.
| Cutoff | Tool | C.up | C.down | NC.up | NC.down | NRI | 95% CI |
|---|---|---|---|---|---|---|---|
| 0.01 | BRCAPROLYTE | 0.04 | 0 | 0.23 | 0 | -0.19 | (-0.22, -0.17) |
| BRCAPRO-1Degree | 0.03 | 0.01 | 0.22 | 0.01 | -0.19 | (-0.22, -0.17) | |
| BRCAPROLYTE-Plus | 0.01 | 0.03 | 0.04 | 0.07 | 0 | (-0.02, 0.03) | |
| BRCAPROLYTE-Simple | 0.02 | 0 | 0.11 | 0.01 | -0.09 | (-0.11, -0.07) | |
|
| |||||||
| 0.05 | BRCAPROLYTE | 0.13 | 0 | 0.28 | 0 | -0.15 | (-0.18, -0.12) |
| BRCAPRO-1Degree | 0.1 | 0.07 | 0.21 | 0.05 | -0.13 | (-0.17, -0.1) | |
| BRCAPROLYTE-Plus | 0.02 | 0.05 | 0.02 | 0.07 | 0.01 | (-0.01, 0.04) | |
| BRCAPROLYTE-Simple | 0.06 | 0.01 | 0.09 | 0.02 | -0.01 | (-0.04, 0.01) | |
|
| |||||||
| 0.1 | BRCAPROLYTE | 0.14 | 0 | 0.25 | 0 | -0.1 | (-0.14, -0.07) |
| BRCAPRO-1Degree | 0.1 | 0.09 | 0.18 | 0.05 | -0.12 | (-0.15, -0.07) | |
| BRCAPROLYTE-Plus | 0.01 | 0.07 | 0.01 | 0.06 | -0.01 | (-0.04, 0.01) | |
| BRCAPROLYTE-Simple | 0.05 | 0.02 | 0.08 | 0.02 | -0.03 | (-0.06, -0.01) | |