TABLE 2.

Summary of association analysis results under the linkage peak for SNPs nominally significantly associated with CaD in both AAs and EAs using SAGE GWAS dataset

SNP	Position1	Function	Gene	African-Americans (275 cases/401 controls)						European-Americans (422 cases/1049 controls)
				MA	MAF (Cases)	MAF (Conts)	OR	95% CI	P	MA	MAF (Cases)	MAF (Conts)	OR	95% CI	P
rs931874	25301315	Intronic	DOCK5	T	0.19	0.24	0.74	0.56–0.99	0.043	T	0.38	0.36	1.20	1.00–1.43	0.05
rs6558049	28148960	Intergenic	-	A	0.23	0.18	1.41	1.05–1.89	0.021	A	0.026	0.045	0.54	0.33–0.90	0.017
rs7015363	28159947	Intergenic	-	G	0.23	0.18	1.36	1.02–1.81	0.037	G	0.026	0.046	0.53	0.32–0.88	0.013
rs7011660	30405716	Intronic	RBPMS	A	0.19	0.23	0.74	0.56–0.98	0.038	A	0.19	0.22	0.77	0.62–0.95	0.016
rs7833229	30542430	Intronic	RBPMS	A	0.024	0.042	0.45	0.22–0.90	0.025	A	0.11	0.14	0.74	0.57–0.97	0.031
rs17664708	32556559	Intronic	NRG1	T	0.049	0.020	2.93	1.47–5.85	0.0022	T	0.13	0.096	1.38	1.05–1.81	0.020
rs12155970	34064572	Intergenic	-	C	0.065	0.034	2.20	1.26–3.86	0.0057	C	0.093	0.062	1.51	1.09–2.09	0.012
rs2593095	38587762	Intergenic	-	T	0.54	0.48	1.27	1.00–1.61	0.049	T	0.33	0.39	0.77	0.64–0.93	0.0056
rs6989042	40301460	Intergenic	-	G	0.30	0.23	1.32	1.01–1.73	0.041	G	0.23	0.20	1.25	1.01–1.55	0.037
rs7826645	40924370	Intergenic	-	A	0.13	0.16	0.68	0.49–0.96	0.026	A	0.16	0.11	1.50	1.17–1.93	0.0016
rs12547609	41091390	Intergenic	-	C	0.15	0.21	0.68	0.50–0.93	0.015	C	0.21	0.17	1.31	1.05–1.63	0.018

CaD, cannabis dependence; SNP, single nucleotide polymorphism; MA, minor allele; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; Conts, Controls;

¹Coordinate based on Genome Build 36.3. Association tests are adjusted by sex, age and the top 10 principal components. Prioritized SNP (rs17664708) for follow up study is shown in bold.