Fig. 3.

CB₁ receptor expression at neuropeptide Y (NPY) interneurons in full-length HD mouse models and human patients with HD. (A) sq-IHC analysis of striatal sections from wild-type and Hdh^Q150/Q150 or BACHD mice co-labeled for CB₁ receptor, and neuropeptide Y (NPY) to quantify the expression of CB₁ receptor at NPY interneurons [n = 3 mice (Hdh150^Q150/Q150 group), 3–4 mice (BACHD group); *P < 0.05]. (B) CB₁ receptor expression in NPY interneurons of the caudate and putamen of post mortem patients with HD compared with non-HD patients (control; n = 5 patients per condition, ***P < 0.001). All values are expressed as mean ± SEM normalized to age-matched wild-type CB₁ receptor expression, and analysed by two-tailed Student’s t-test to their wild-type littermates.