Table 4.

Univariate and multivariate regression analysis for DFS and OS in the whole cohort

Variables	Disease-free survival						Overall survival
	Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
	HR	95% CI	P value*	HR	95% CI	P value*	HR	95% CI	P value*	HR	95% CI	P value*
Age†	1.258	0.872-1.813	0.219	.....	.....	.....	1.359	0.933-1.981	0.110	.....	.....	.....
Gender‡	0.832	0.535-1.295	0.416	.....	.....	.....	0.759	0.478-1.205	0.242	.....	.....	.....
Location§	0.763	0.558-1.043	0.090	.....	.....	.....	0.751	0.542-1.040	0.084	.....	.....	.....
Surgery¶	1.034	0.851-1.256	0.738	.....	.....	.....	1.052	0.863-1.284	0.615	.....	.....	.....
pT status¿	1.133	0.782-1.644	0.509	.....	.....	.....	1.118	0.772-1.618	0.554	.....	.....	.....
Differentiation£	1.393	1.065-1.823	0.016	1.411	1.086-1.833	0.010	1.319	1.004-1.734	0.047	1.331	1.020-1.738	0.035
pN statusð	3.211	2.198-4.692	< 0.001	3.096	2.131-4.498	< 0.001	3.032	2.056-4.471	< 0.001	2.926	1.998-4.286	< 0.001
Cystatin SNζ	0.431	0.271-0.685	< 0.001	0.426	0.270-0.672	< 0.001	0.377	0.231-0.616	< 0.001	0.378	0.233-0.614	< 0.001

^*Cox proportional hazards model; ^†Age ≤ 57 vs. Age > 57; ^‡Male vs. Female; ^§Upper thoracic vs. Middle thoracic vs. Lower thoracic; ^¶Left thoracotomy vs. Thoracic-abdominal-cervical incision; ^¿pT1 vs. pT2 vs. pT3 vs. pT4; ^£Tumor grade 1 vs. Tumor grade 2 vs. Tumor grade 3; ^ðpN0 vs. pN1/2/3; ^ζHigh expression of Cystatin SN vs. low expression of Cystatin SN. HR hazard ratio, CI confidence interval, pT pathologic tumor, pN pathologic node.