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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Stroke. 2013 Jun;44(6 0 1):S93–S95. doi: 10.1161/STROKEAHA.112.678698

Figure 2. Changes in AQP4 localization after diffuse injury.

Figure 2

(A) Immunofluorescent double-labeling demonstrates that in the healthy young mouse brain, AQP4 expression is highly localized to perivascular astrocytic endfeet surrounding to entirety of the cerebral microvasculature. (B) 7 days after mild traumatic brain injury, widespread reactive astrogliosis (GFAP-immunoreactivity) is observed throughout the ipsilateral cortex. In regions of reactive astrogliosis, AQP4 localization is severely perturbed, exhibiting a loss of polarization to the endfoot process and increased somal labeling. Similar expression patters are observed after diffuse microinfarction (manuscript under review).