Table 2.
Univariate and multivariate Cox regression analyses of overall survival in 100 HCC patients following LT
| Parameter |
Univariate analysis |
Multivariable analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age |
0.875 |
0.912-1.172 |
0.169 |
- |
- |
- |
| Gender |
1.034 |
0.561-1.907 |
0.915 |
- |
- |
- |
| HBV infection |
0.342 |
0.261-0.745 |
0.230 |
- |
- |
- |
| Cirrhosis |
0.833 |
0.495-1.438 |
0.467 |
- |
- |
- |
| Tumor size |
1.319 |
1.012-1.894 |
0.021* |
1.175 |
0.981-1.857 |
0.035* |
| Tumor stage (III) |
2.938 |
1.359-5.493 |
0.018* |
2. 354 |
0.846-2.943 |
0.851 |
| Histologic grade (G3/G1-2) |
3.342 |
1.837-6.421 |
0.009* |
1.773 |
0.732-3.101 |
0.082 |
| Milan criteria (out) |
1.756 |
1.043-3.433 |
0.017* |
1.365 |
0.935-2.778 |
0.347 |
| AFP >400 (ng/ml) |
2.027 |
1.386-3.543 |
0.023* |
1.569 |
1.031-4.603 |
0.031* |
| Micro-vascular invasion |
3.739 |
1.929-6.758 |
0.005* |
2.671 |
1.756-5.545 |
0.009* |
| miR-20a (low) | 4.483 | 2.769-9.572 | 0.009* | 4.937 | 2.221-9.503 | 0.022* |
Note: *statistically significant difference.