Table 3.
Univariate and multivariate Cox regression analyses of recurrence-free survival in 100 HCC patients following LT
| Parameter |
Univariate analysis |
Multivariable analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age |
0.849 |
0.713-1.275 |
0.746 |
- |
- |
- |
| Gender |
1.092 |
0.534-2.801 |
0.331 |
- |
- |
- |
| HBV infection |
0.583 |
0.228-1.144 |
0.192 |
- |
- |
- |
| Cirrhosis |
0.746 |
0.434-1.204 |
0.493 |
- |
- |
- |
| Tumor size |
1.632 |
1.031-1.918 |
0.011* |
1.253 |
1.123-1.792 |
0.014* |
| Tumor stage (III) |
1.876 |
1.319-2.592 |
0.026* |
1.348 |
0.935-1.813 |
0.365 |
| Histologic grade (G3/G1-2) |
3.731 |
1.774-5.103 |
0.024* |
2.931 |
1.526-3.858 |
0.079 |
| Milan criteria (out) |
2.182 |
1.962-6.212 |
0.018* |
1.935 |
1.332-3.563 |
0.156 |
| AFP >400 (ng/ml) |
1.939 |
1.638-4.809 |
0.012* |
2.235 |
1.771-4.595 |
0.028* |
| Micro-vascular invasion |
4.017 |
3.137-7.583 |
0.009* |
3.643 |
2.964-6.927 |
0.012* |
| miR-20a (low) | 4.591 | 2.933-8.457 | 0.015* | 4.281 | 3.316-6.741 | 0.013* |
Note: *statistically significant difference.