Figure 6.

Model for MyD88 inhibition alone or in combination with cisplatin in Ras-dependent cells. A) Ras pathway optimal activation in presence of MyD88 induces DNA repair enzyme ERCC1, enabling efficient DNA repair mechanisms in cancer cells. B) Absence of MyD88 leads to the inactivation of the canonical Ras/Erk pathway, therefore decreasing the expression of DNA repair enzyme ERCC1 and reducing cellular DNA repair abilities, leading to an accumulation of DNA damage and activating the apoptotic program via p53. C) Combining MyD88 inhibition with cisplatin enhances DNA damage accumulation and increases cell death.