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. 2013 Jul 2;8(7):e67773. doi: 10.1371/journal.pone.0067773

Figure 8. Wnt1 increases mitochondrial motility and dynamics.

Figure 8

Series of representative confocal images, taken every 225 sec, from live HEK293T cells overexpressing the mitochondrial tagged protein MitDsRed (A), Alex3-GFP fusion protein (B), or Alex3-GFP and Wnt1 cDNAs (4∶1) (C,D). In (D) TPA treatment was used to activate PKC. Arrows identify areas with highly dynamic mitochondria. While mitochondrial motility is high in control (A) and Alex3-GFP/Wnt1 (C) conditions, it is severely reduced in Alex3-GFP-overexpressing cells (B) and in Alex3-GFP/Wnt1/TPA-treated cells (D). (See also Videos S1, S2, S3, and S4). Scale bar: 10 µm.