Table 2. Biomechanical parameter changes in APN KO and WT mice upon OVX surgery.

	Energy (mJ)		Maximum Load(N)		Maximum Stress (Mpa)
	lumbar	femur	lumbar	femur	lumbar	femur
WT.Sham	24.39±2.49	4.45±0.13	50.69±10.50	23.33±0.90	0.59±0.01	105.03±5.41
WT.OVX	14.24±2.82**	3.06±0.18**	28.69±4.67**	17.53±1.99**	0.38±0.04**	92.87±9.60*
KO.Sham	20.92±8.04	3.31±0.53	47.74±2.53	21.04±0.79	0.64±0.06	160.25±10.07
KO.OVX	20.53±6.64	3.48±0.67	42.07±4.11	22.62±3.04	0.54±0.05	146.73±1.86

Note: Mean values ± SD are shown. WT.Sham, n = 5; WT.OVX, n = 6; KO.Sham, n = 6; KO.OVX, n = 7.

^*indicates significant differences between WT.OVX and WT.Sham mice at p<0.05,

^**indicates significant differences between WT.OVX and WT.Sham mice at p<0.01.