Figure 1. Loss of CFH causes thickening of the retina and reduced nuclear density in the outer nuclear layer.

Toluidine blue stained 2 µm semithin sections of (A and B) wild-type and (C and D) Cfh ^−/− mouse eyes at age 7–8 weeks (A and C) and one year (B and D). Retinal thickness (E) was calculated from the ILM to RPE. Data are means ± S.D., n = 3. Average nuclei number (F) was calculated per 100 µm² area of the ONL. Data are means ± S.D., n = 5. Student t-tests were applied to data, *p = <0.05. Scale bar represents 20 µm.