. 2013 Jul 2;8(7):e65629. doi: 10.1371/journal.pone.0065629

Table 5. Identity of ion transporter and associated enzyme genes.

Protein ID	Transport Function	Gene ID	E15 Enriched Genes (from RNA-Seq)	Additional Genes with Unaltered Expression (from RNA-Seq)	Adult Enriched Genes (from RNA-Seq)
Na⁺/K⁺ ATPase	Na⁺/K⁺	Atp1b1		Atp1a3	Atp1a1, Atp1b1, Atp1b2, Atp1b3
Carbonic anhydrase 2	H⁺/HCO₃ ⁻ synthesis	Car2	Car1, 8, 10	Car6, 9	2, 3, 4, 5b, 12, 13, 14
NKCC1	Na⁺/K⁺/Cl⁻	Slc12a2			Slc12a2
NBCe2	Na⁺/HC0₃ ⁻	Slc4a5			Slc4a5
NHE1	cation proton antiporter	Slc9a1	Slc9a5 (NHE5)	Slc9a1	Slc9a6 (NHE6), Slc9a7 (NHE7)
NaBC1	sodium borate/HCO₃ ⁻/anion	*Slc4a11*	Slc4a3, Slc4a4
NBCn1	Na⁺/HCO₃ ⁻	Slc4a7	Slc4a4
NCBE/NBCn2	Na⁺/HCO₃ ⁻/Cl⁻	Slc4a10			Slc4a10
NCC	Na⁺/Cl⁻				Slc12a3
	Na⁺/K⁺/Ca²⁺				Slc24a3
KCC3	K⁺/Cl⁻	*Slc12a6*			Slc12a4 (KCC1)
KCC4	K⁺/Cl⁻	Slc12a7		Slc12a7	Slc12a4 (KCC1)
AE2	Cl⁻/HCO₃ ⁻	Slc4a2			Slc4a2
AE1	Cl⁻/HCO₃ ⁻	Slc4a1	Slc4a1

Enzymes and ion transporters known to be involved in CSF secretion. Protein ID from [72]; these ion transporters have been shown to be active in adult choroid plexus; as an example the cellular localization of SLC4A1 is shown in Fig. 3C, D . Gene ID and function from NCBI (http://www.ncbi.nlm.nih.gov/gene). Genes in bold were not detected in either RNA-Seq or Affymetrix datasets. Slc4a7 was only identified in Affymetrix. Slc12a2 (NKCC1) has previously been identified in embryonic mouse choroid plexus as has Slc12a4 (KCC1) [110] and Slc4a10 (NCBE) [111]. Genes underlined have not previously been identified in rat choroid plexus (but cf. with mouse choroid plexus [13]). A comprehensive list is presented in S2. Most of the genes listed here were identified in both RNA-Seq and Affymetrix datasets.