Figure 1.

The rate of cardiac myofibrillar protein synthesis is decreased in the cachectic Apc^Min/+ mouse. Protein synthesis in mice were determined in whole hearts from 20-week-old BL6 and Apc^Min/+ mice by tandem mass spectrometry after intraperitoneal injection of ²H₅-phenylalanine. Percentage protein synthesis/day was calculated from the ratio of radioactivity in the myofibrillar protein pellet to that observed in the free amino acid pool. Mean values ± SEM (A) and raw data (B). An asterisk (^*) indicates significant differences in Apc^Min/+ mice from the BL6 age-matched controls (n=6–7 per group, P<0.05).