Figure 8.

Schematic representation of different pathways involved in cancer-induced cardiac cachexia in 12- and 20-week-old Apc^Min/+ mice. Recent studies along with the data obtained in the present study suggest that cancer cachexia is characterized by gradual increase in protein degradation and decrease in protein synthesis with age. Solid arrows correspond to increase or decrease in activation of the respective protein in the 12- and 20-week-old Apc^Min/+ mice compared with age-matched BL6 controls.