Table IV.
Summary of clinicopathological features of the MI-FTC patients in this study.
| M(+) n=12 | M(−) n=22 | P-value | |
|---|---|---|---|
| Sex | |||
| Female/male | 7/5 | 16/6 | 0.315e |
| Age | 54.5±15.2 | 43.3±14.4 | 0.028f |
| Tumor size (mm) | 56.8±24.5 | 43.2±16.3 | 0.094f |
| Operation method | |||
| Lo/ST+ TT | 7/5 | 19/3 | 0.080e |
| Tg (ng/ml)a | |||
| Pre-operation | 3388.5±3511.0 | 926.5±1097.3 | 0.217f |
| Post-operation | 32.8±54.0 | 14.6±12.1 | 0.986f |
| Invasionb | |||
| Capsular invasion +/− | 11/1 | 22/0 | 0.353e |
| Vascular invasion +/− | 9/3 | 5/17 | 0.005e |
| Distant metastasis after surgery | |||
| Period (month) | 51.1±26.1 | na | |
| Location | |||
| Lung | 8 | na | |
| Bone | 7 | ||
| Additional therapiesc | 10 | na | |
| Expression level of miRNAsd | |||
| miR-221 | 43.792±41.809 | 9.351±21.818 | <0.001f |
| miR-222 | 97.800±84.473 | 22.455±42.031 | <0.001f |
| miR-222* | 0.372±0.250 | 0.102±0.150 | <0.001f |
| miR-10b | 0.149±0.088 | 0.045±0.045 | <0.001f |
| miR-92a | 9.032±5.597 | 4.137±3.637 | <0.001f |
| miR-375 | 0.136±0.209 | 0.065±0.086 | 0.309f |
Lo, right or left thyroid lobectomy; ST, subtotal thyroidectomy; TT, total thyroidectomy; na, not applicable.
Thyroglobulin (Tg, normal range 2.0–35.0 ng/ml) is used as a post-operative marker for the follow-up of patients with thyroid carcinoma. The Tg values were abnormal before the operation, but were reduced to within the normal range after the operation in almost all cases.
Invasion: +, present; −, absent.
Additional therapies mean a combination of total thyroidectomy and radioiodine ablation therapy or radioiodine ablation therapy.
The expression levels of these miRNAs were absolutely quantified and shown as the values normalized for the expression level of RNU44 in each sample; miRNA (amol/μl)/RNU44 (amol/μl).
χ2 test.
Mann-Whitney U test; the results are expressed as mean ± SD.