Figure 1. 5.

′UTRs of nicotine dependence-associated nAChR subunit genes with putative uORFs. The bp position for each uORF (start/stop) is depicted starting from the main start codon in 5′- direction. CHRNA4 isoform 1 and isoform 2 differ in their coding region, with a further downstream translation initiation for isoform 2, that elongates its 5′UTR. CHRNA4 isoform 2 was not published until 2012 and has not been functionally analysed before. Squares, uORFs; arrows, SNPs