Table 4. Effect of treatment on histological outcomes following 3 months of treatment.

Measurement	Vehicle		LANZO		PRED		Combined		Significantly different means/medians
	N	Median (Range)	N	Median (Range)	N	Median (Range)	N	Median (Range)
Degenerating fibers per field (gastrocnemius)**	6	12 (3–13)	5	12 (3–33)	5	2 (1–9)b, ab	5	6 (1–7)c, ac	bVeh vs. PRED (p = 0.002); cVeh vs. Combined (p = 0.018); abLANZO vs. PRED (p = 0.001); acLANZO vs. Combined (p = 0.005)
Regenerating fibers per field (gastrocnemius) **	6	5 (0–17)	5	8 (3–25)	5	0 (0–17)	5	3 (1–10)	NONE
Inflammatory foci per field (gastrocnemius) **	6	11 (6–40)	5	7 (5–10)a	5	7 (3–17)b	5	5 (3–7)c	aVeh vs. LANZO (p = 0.008); bVeh vs. PRED (p = 0.012); cVeh vs. Combined (p<0.001)
Inflammatory foci per field (diaphragm)	6	59±16	6	56±16	6	57±17	6	46±15	NONE
Fibrosis (diaphragm)	5	22.0±4.7	5	24.2±9.6	5	18.5±3.9	5	18.9±3.7	NONE

Footnotes:

^**Histology compared between groups using Poisson regression.