Table 3.
Laboratory abnormalities in patients with associated MDS and AD from five series
| Presentation | Ref# 3 | Ref# 9 | Ref# 4 | Ref# 5 | Ref# 7 | Median (%) |
|---|---|---|---|---|---|---|
| AD (% of patients) | 13/70 (19) | 21/84 (25) | 40/221 (18) | N/A | N/A | 19 |
| Hypergammaglobulinemia (% of AD) | 10/13 (76) | Present† | 9/40 (22) | 50/128 (39) | 90/284 (31) | 35 |
| ANA (% of AD) | 4/13 (30) | 6/21 (28) | 14/40 (35) | 35/115 (30) | 67/284* (23) | 30 |
| RF (% of AD) | 3/13 (23) | 18/21 (85) | 2/40 (5) | 16/115 (14) | * | 18.5 |
| Hypocomplementemia (% of AD) | - | - | 7/40 (17) | - | - | 17 |
| DAT (% of AD) | 3/13 (23) | 6/21 (28)‡ | 6/40 (15) | 13/108 (12) | 14/2 (5) | 15 |
| Cryoglobulins (% of AD) | - | - | 5/40 (12) | - | - | 12 |
| Antiphospholipids antibodies (% of AD) | - | - | 4/40 (10) | - | - | 10 |
| Hypogammaglobulinemia (% of AD) | 1/13 (7) | - | 2/40 (5) | 11/128 (8) | 42/284 (14) | 7.5 |
| Anti DsDNA (% of AD) | - | - | - | 8/110 (7) | - | 7 |
| AMA (% of AD) | 1/13 (7) | - | 1/40 (2.5) | - | * | 4.75 |
| Antiplatelets antibodies (% of AD) | 1/13 (7) | - | - | 2/153 (1) | - | 4 |
*
Combined ANA, RF and AMA reported values
†
Only mean gammaglobulin value is available
‡
Higher than weak positive result
ASMA was reported in one study in 1/40 patients (2.5%)
Abbreviations: AD, autoimmune disease; AMA, anti-mitochondrial antibodies; ANA, antinuclear antibodies; ASMA, anti-smooth muscle antibodies; DAT, direct antiglobulin test; RF, rheumatoid factor;