Table 1. Top 40 Most Heavily Acetylated Proteins in the Heart (by Site Count).
| Cell Compartment | Process | Ensembl Proteins | Gene | Protein description | Sites | |||
| Sarcomere | Myofilament | ENSCPOP00000006354* | MYH7 | Beta-Myosin Heavy Chain. | 49 | |||
| Extcell | Lipid Binding | ENSCPOP00000002782* | ALB | Preproalbumin Precursor. | 25 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000005365* | HADHA | Hydroxyacyl-CoA Dehydrogenase/3-ketoacyl-coa Thiolase/Enoyl-coa Hydratase (Trifunctional Protein), Alpha Subunit | 25 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000007630* | IDH2 | Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial | 23 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000008228* | GOT2 | Glutamic-oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) | 19 | |||
| Mitochondrion | Chaperone | ENSCPOP00000016987* | HSPD1 | Heat Shock 60 kda Protein 1 (Chaperonin) | 17 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000004776* | DLD | Dihydrolipoamide Dehydrogenase | 15 | |||
| Cytoplasm | Phosphotransfer | ENSCPOP00000016471* | CKM | Creatine Kinase, Muscle | 15 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000019095* | MDH2 | Malate Dehydrogenase (EC 1.1.1.37) (Fragment). | 15 | |||
| Mitochondrion | Redox | ENSCPOP00000002046* | NNT | Nicotinamide Nucleotide Transhydrogenase | 13 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000003628* | ATP5H | ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit D | 13 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000004744* | SLC25A4 | Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 4 | 13 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000004877* | HADHB | Hydroxyacyl-CoA Dehydrogenase/3-ketoacyl-coa Thiolase/Enoyl-coa Hydratase (Trifunctional Protein), Beta Subunit | 13 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000011443* | ATP5A1 | ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Alpha Subunit 1, Cardiac Muscle | 12 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000009450* | ATP5C1 | ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1 | 11 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000011373* | ACO2 | Aconitase 2, Mitochondrial | 11 | |||
| Mitochondrion | Chaperone | ENSCPOP00000002148* | HSPA9 | Heat Shock 70kda Protein 9 (Mortalin) | 10 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000004266* | ACAA2 | Acetyl-CoA Acyltransferase 2 | 10 | |||
| Nucleus | Histone | ENSCPOP00000015130* | HIST1H2BE | Novel Transcript [Type: Protein Coding Ensembl] | 10 | |||
| Cytoplasm | O2 Carrying | ENSCPOP00000001378* | HBB | Hemoglobin Subunit Beta (Hemoglobin Beta Chain) (Beta-globin). | 9 | |||
| Nucleus | Transcription | ENSCPOP00000004894* | EP300 | E1A Binding Protein P300 | 9 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000006024* | UQCRC2 | Ubiquinol-cytochrome C Reductase Core Protein II | 9 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000008014* | SDHA | Succinate Dehydrogenase Complex Subunit A. | 9 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000008332* | PDHA1 | Pyruvate Dehydrogenase E1 Component Subunit Alpha Somatic Form MitochondrialPrecursor Ec_1.2.4.1 Pdhe1a Type I | 9 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000008856* | ACADL | Acyl-CoA Dehydrogenase, Long Chain | 9 | |||
| Mitochondrion | Mito Ion | ENSCPOP00000009440* | VDAC3 | Voltage-dependent Anion Channel 3 | 9 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000010349* | CPT2 | Carnitine Palmitoyltransferase 2 | 9 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000013564* | ACAT1 | Acetyl-CoA Acetyltransferase 1 | 9 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000015742* | HADH | Hydroxyacyl-coa Dehydrogenase | 9 | |||
| Nucleus | Histone | ENSCPOP00000016731* | HIST2H2BF | Histone Cluster 2, H2bf | 9 | |||
| Mitochondrion | Proteolysis | ENSCPOP00000010265* | C21orf33 | ES1 Mitochondrial Precursor | 8 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000012673* | ATP5F1 | ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B1 | 8 | |||
| Mitochondrion | Mito FAO | ENSCPOP00000014862* | ACADVL | Acyl-coa Dehydrogenase, Very Long Chain | 8 | |||
| Sarcomere | Myofilament | ENSCPOP00000016138 | TNNI3 | Troponin I Type 3 (Cardiac) | 8 | |||
| Mitochondrion | Redox | ENSCPOP00000000012* | ALDH6A1 | Aldehyde Dehydrogenase 6 Family, Member A1 | 7 | |||
| Mitochondrion | Mito TCA | ENSCPOP00000002733* | SUCLG1 | Succinate-CoA Ligase, Alpha Subunit | 7 | |||
| Nucleus | Histone | ENSCPOP00000004239* | H3F3A | Histone H3 | 7 | |||
| Cytoplasm | O2 Carrying | ENSCPOP00000006188* | MB | Myoglobin | 7 | |||
| Mitochondrion | Mito FAS | ENSCPOP00000011954* | ACSF2 | Acyl-CoA Synthetase Family Member 2 | 7 | |||
| Mitochondrion | Mito Oxphos | ENSCPOP00000016071* | ATP5B | ATP Synthase Subunit Beta (EC 3.6.3.14) (Fragment). | 7 | |||
Top 40 Most Heavily Acetylated Proteins (by Number of Acetyl-Lysine Residues). Asterisks (*) designate the accessions of acetyl-proteins identified in all three biological replicates.