Fig. 2.

Time-dependent behavior of Iba-1-, and CD45-positive cells in ATP-injected rat brain substantia nigra. Serial sections obtained 3 hours to 83 days after ATP injection ("*" denotes injection sites) were immunostained for Iba-1 (A) and CD45 (B). The lower panels in (A) represent higher magnification images of the indicated areas in the upper panels. Black arrowheads at 3 h indicate dead cells. White arrows and white arrowheads in (A) indicate thick and short process-bearing Iba-1-positive cells. Black arrows in (A) at 2 d represent round Iba-1-positive cells. CD45-positive cells were found around blood vessels (B, inset). Scale bars: 200 µm (A upper panel, B) and 100 µm (A lower panel). (Adapted from Jeong et al., PLoS One, 2010).