Figure 7.

Prevention of diabetes-induced increase in leukocyte adhesion by arginase deletion. Wild type controls, wild type diabetic or arginase AI^+/−AII^−/− (KO) diabetic mice were perfused through left ventricle with Concanavalin A to label leukocytes attached to the vascular endothelium. The number of attached leukocytes was significantly increased in the wildtype diabetic mice as compared to non-diabetic controls and arginase KO significantly blunted this effect (*p < 0.05 vs. control, #p < 0.05 vs. diabetic wildtype, n = 5, scale bar = 100 μM).