Table 1.
Characteristics* of the 24 Studies Participating in the Pooled Analysis
| Study | Location | Recruitment Period | Matching Factors | Histology Source† | White Race, % | Mean Age, Years‡ | No. of Cases |
No. of Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Endometrioid | Adenocarcinoma NOS | Adenocarcinoma With Squamous Differentiation | Serous | Mixed Cell | Clear Cell | Mucinous | ||||||||
| Cohort studies | ||||||||||||||
| Breast Cancer Detection Demonstration Project (BCDDP) | 29 US clinics | 1979-1980 | Birth year, cohort entry, race, clinic | Path | 92.6 | 65.2 | 48 | 276 | 27 | 10 | 1 | 4 | 1,858 | |
| Cancer Prevention Study II (CPS-II) Nutrition Cohort | 21 US states | 1992 | Birth year, cohort entry, race, area | Path/registry | 98.7 | 68.9 | 205 | 270 | 18 | 30 | 2 | 9 | 16 | 2,431 |
| Canadian National Breast Screening Study (NBSS) | Canada | 1980-1985 | Birth year, cohort entry, race, area | Registry | 96.9 | 59.9 | 149 | 396 | 49 | 23 | 1 | 9 | 12 | 2,953 |
| California Teachers Study (CTS) | California | 1995-1996 | Birth year, cohort entry, race, area | Registry | 91.9 | 64.7 | 367 | 173 | 27 | 19 | 23 | 6 | 16 | 2,539 |
| Iowa Women's Health Study (IWHS) | Iowa | 1986 | Birth year, cohort entry, race, area | Registry | 98.7 | 71.6 | 99 | 316 | 26 | 26 | 2 | 6 | 3 | 2,120 |
| Multiethnic Cohort (MEC) | Hawaii, California | 1993-1996 | Birth year, cohort entry, race, area | Registry | 28.1 | 65.6 | 235 | 187 | 26 | 29 | 10 | 13 | 6 | 2,341 |
| Nurses' Health Study (NHS) | 11 US states | 1976 | Birth year, race | Path | 94.8 | 62.4 | 430§ | 23 | 4 | 9 | 1,271 | |||
| NIH-AARP Diet and Health Study (NIH-AARP) | 8 US areas | 1995-1996 | birth year, cohort entry, race, area | Registry | 93.9 | 67.5 | 809 | 495 | 39 | 71 | 23 | 19 | 29 | 6,831 |
| Netherlands Cohort Study (NLCS) | Netherlands | 1986 | birth year, cohort entry | Path/registry | 100.0 | 69.6 | 98 | 182 | 43 | 5 | 14 | 3 | 766 | |
| Swedish Mammography Cohort (SMC) | Sweden | 1987-1990 | Birth year, cohort entry | Registry | 100.0 | 70.5 | 293 | 3 | 10 | 4 | 1 | 1,283 | ||
| All cohort studies | 61.0 | 66.4 | 2,440 | 2,588 | 281 | 227 | 61 | 90 | 90 | 24,393 | ||||
| Case-control studies | ||||||||||||||
| Alberta | Canada | 2002-2006 | Age (± 5 years) | Path/registry | 94.8 | 58.3 | 424 | 15 | 8 | 18 | 15 | 10 | 4 | 1,026 |
| Australian National Endometrial Cancer Study (ANECS) | Australia | 2005-2007 | Age (5-year group), state | Path | 88.6 | 61.2 | 861 | 1 | 164 | 49 | 132 | 21 | 3 | 703 |
| Bay Area Women's Health Study (BAWHS) | California | 1996-1999 | Age (5-year group), ethnicity | Registry | 90.3 | 61.8 | 178 | 199 | 10 | 15 | 11 | 20 | 445 | |
| Connecticut Endometrial Cancer Study (CECS) | Connecticut | 2004-2009 | Age (5-year group) | Path | 93.2 | 61.5 | 502 | 22 | 5 | 35 | 23 | 9 | 9 | 627 |
| Estrogen, Diet, Genetics, and Endometrial Cancer (EDGE) | New Jersey | 2001-2005 | Age (5-year group) | Registry | 90.1 | 62.8 | 292 | 96 | 9 | 26 | 6 | 4 | 3 | 464 |
| Fred Hutchinson Cancer Research Center (FHCRC) | Washington | 1994-2005 | Age (5-year group) | Registry | 95.5 | 59.7 | 463 | 260 | 35 | 35 | 20 | 3 | 6 | 847 |
| Hawaii Endometrial Cancer Study (HAW) | Hawaii | 1988-1993 | Age (± 2.5 years), ethnicity | Path/registry | 29.1 | 62.5 | 93 | 192 | 19 | 4 | 3 | 2 | 3 | 335 |
| Polish Endometrial Cancer Study (PECS) | Poland | 2000-2003 | Age (± 5 years), site | Path/slide | 100.0 | 57.2 | 312 | 110 | 10 | 68 | 5 | 4 | 1,829 | |
| Patient Epidemiologic Data System (PEDS) | New York | 1982-1998 | Age (± 5 years) | Registry | 97.4 | 62.9 | 72 | 327 | 33 | 19 | 5 | 8 | 2 | 504 |
| Shanghai Endometrial Cancer Study (SECS) | China | 1997-2004 | Age (± 5 years) | Path/slide | 0.0 | 54.6 | 997 | 60 | 7 | 15 | 3 | 8 | 2 | 1,205 |
| Turin Case Control Study (TURIN) | Italy | 1998-2008 | — | Path | 100.0 | 60.9 | 180 | 12 | 4 | 9 | 3 | 10 | 2 | 266 |
| US Endometrial Cancer Study (US) | 5 US clinics | 1987-1990 | Age (± 5 years), race, telephone exchange | Path | 93.1 | 58.8 | 18 | 224 | 47 | 11 | 1 | 7 | 10 | 303 |
| USC LA case-control (USC) | Los Angeles | 1987-1993 | Age (± 5 years) | Path | 100.0 | 63.1 | 38 | 666 | 45 | 7 | 1 | 8 | 791 | |
| Women's Insight and Shared Experience (WISE) | Philadelphia | 1999-2002 | Age (± 5 years), race | Path | 78.9 | 61.7 | 376 | 168 | 28 | 6 | 7 | 1,574 | ||
| All case-control studies | 79.7 | 60.0 | 4,806 | 2,242 | 496 | 281 | 285 | 106 | 76 | 10,919 | ||||
| Pooled studies | 85.4 | 63.9 | 7,246 | 4,830 | 777 | 508 | 346 | 196 | 166 | 35,312 | ||||
Abbreviations: AARP, American Association of Retired Persons; NIH, National Institutes of Health; NOS, not otherwise specified.
*
Based on women included in the pooled analysis (ie, after excluding women with missing risk factor data).
†
Path = review of pathology report; slide = review of pathology slides; registry = histologic type/code as reported to a cancer registry.
‡
Age at diagnosis for cases and age at interview/reference date for controls.
§
NHS grouped endometrioid, adenocarcinoma NOS, and mucinous tumors in one category.