Table A2.

Association of Endometrial Cancer Risk Factors With Type I and Type II Tumors by Aspects of Study Design

Risk Factor	Type I								Type II
	Cohort		Case-Control		Path Review		Registry		Cohort		Case-Control		Path Review		Registry
	OR*	95% CI	OR*	95% CI	OR*	95% CI	OR*	95% CI	OR*	95% CI	OR*	95% CI	OR*	95% CI	OR*	95% CI
Body mass index, kg/m2
< 25	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
25 to < 30	1.32	1.23 to 1.43	1.60	1.48 to 1.73	1.53	1.40 to 1.66	1.40	1.31 to 1.50	1.14	0.86 to 1.52	1.19	0.95 to 1.48	1.08	0.84 to 1.40	1.24	0.98 to 1.57
30 to < 35	2.44	2.23 to 2.67	2.61	2.36 to 2.88	2.45	2.19 to 2.74	2.56	2.35 to 2.78	1.76	1.25 to 2.47	1.72	1.32 to 2.23	1.55	1.13 to 2.12	1.90	1.44 to 2.50
35 to < 40	4.15	3.65 to 4.72	4.84	4.20 to 5.58	4.45	3.76 to 5.26	4.46	3.98 to 5.00	2.22	1.37 to 3.61	2.15	1.48 to 3.11	2.21	1.42 to 3.45	2.12	1.43 to 3.16
≥ 40	6.66	5.66 to 7.83	7.86	6.54 to 9.44	8.45	6.69 to 10.67	6.73	5.83 to 7.75	3.08	1.69 to 5.61	3.29	2.11 to 5.12	4.20	2.44 to 7.23	2.64	1.63 to 4.30
P trend	< .0001		< .0001		< .0001		< .0001		< .0001		< .0001		< .0001		< .0001
Body mass index, per 2 kg/m2	1.20	1.18 to 1.21	1.22	1.20 to 1.23	1.21	1.19 to 1.23	1.20	1.19 to 1.22	1.12	1.08 to 1.17	1.12	1.08 to 1.15	1.13	1.08 to 1.17	1.11	1.08 to 1.15
Age at menarche, years
< 11	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
11-12	0.90	0.78 to 1.04	0.88	0.75 to 1.03	0.90	0.74 to 1.09	0.88	0.77 to 1.00	0.62	0.40 to 0.97	0.72	0.48 to 1.07	0.67	0.40 to 1.11	0.67	0.46 to 0.96
13-14	0.87	0.75 to 0.99	0.83	0.71 to 0.96	0.82	0.68 to 0.97	0.86	0.76 to 0.97	0.52	0.34 to 0.79	0.71	0.49 to 1.03	0.68	0.42 to 1.10	0.58	0.41 to 0.81
≥ 15	0.72	0.61 to 0.86	0.69	0.59 to 0.82	0.68	0.56 to 0.83	0.73	0.63 to 0.84	0.52	0.31 to 0.90	0.52	0.33 to 0.81	0.45	0.26 to 0.78	0.58	0.37 to 0.90
P trend	.0002		< .0001		< .0001		.0001		0.01		.008		.008		.009
Parity
0	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
1	0.80	0.71 to 0.90	0.70	0.59 to 0.76	0.64	0.56 to 0.74	0.79	0.71 to 0.88	1.06	0.69 to 1.61	0.72	0.52 to 1.01	0.67	0.45 to 0.98	0.98	0.69 to 1.40
2	0.77	0.70 to 0.85	0.57	0.51 to 0.63	0.56	0.49 to 0.63	0.73	0.67 to 0.80	0.84	0.59 to 1.21	0.57	0.43 to 0.76	0.51	0.37 to 0.72	0.80	0.60 to 1.07
3	0.63	0.57 to 0.69	0.48	0.43 to 0.54	0.46	0.40 to 0.52	0.61	0.56 to 0.67	0.65	0.46 to 0.93	0.50	0.38 to 0.67	0.46	0.32 to 0.65	0.64	0.48 to 0.85
≥ 4	0.47	0.41 to 0.53	0.32	0.28 to 0.38	0.33	0.28 to 0.39	0.44	0.39 to 0.49	0.58	0.36 to 0.92	0.51	0.36 to 0.74	0.54	0.35 to 0.82	0.51	0.34 to 0.75
P trend	< .0001		< .0001		< .0001		< .0001		.001		< .0001		.0002		< .0001
Oral contraceptive use
Never	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
Ever	0.76	0.71 to 0.82	0.68	0.62 to 0.73	0.68	0.62 to 0.74	0.75	0.70 to 0.81	0.81	0.62 to 1.07	0.68	0.54 to 0.86	0.59	0.44 to 0.79	0.86	0.68 to 1.08
Cigarette smoking†
Never	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
Former	0.88	0.83 to 0.95	0.84	0.78 to 0.91	0.84	0.77 to 0.92	0.88	0.82 to 0.94	0.87	0.67 to 1.12	0.62	0.49 to 0.77	0.60	0.47 to 0.79	0.79	0.63 to 0.98
Current	0.68	0.61 to 0.76	0.61	0.54 to 0.68	0.60	0.52 to 0.68	0.68	0.61 to 0.75	0.73	0.49 to 1.11	0.52	0.38 to 0.72	0.52	0.36 to 0.75	0.66	0.46 to 0.93
Diabetes‡
No	1.00		1.00		1.00		1.00		1.00		1.00		1.00		1.00
Yes	1.21	1.06 to 1.38	1.31	1.18 to 1.47	1.34	1.18 to 1.52	1.24	1.10 to 1.39	1.15	0.73 to 1.82	1.76	1.31 to 2.37	1.53	1.05 to 2.24	1.55	1.13 to 2.14

Abbreviation: OR, odds ratio.

^*Stratified by age, study, and race/ethnicity and mutually adjusted for body mass index, age at menarche, parity, oral contraceptive use, and smoking status.

^†Based on 23 studies with smoking data.

^‡Based on 19 studies with diabetes data.