Figure 4.

(A) 2D ¹³C-¹³C DARR NMR spectrum of Sample A showing long-range (up to ∼0.6 nm) contacts between labeled sites. Solid lines indicate single-bond assignment pathways for each ¹³C-labeled residue. Contacts between V3 and K17 are indicated with circles. (B) Horizontal slices at peak frequencies of V3 C_α, T12 C_β, and K17 C_α signals. Vertical dotted lines indicate polarization transfers between the V3 and K17 signals. (C) A molecular model indicating relative positions of labeled residues within a β-hairpin.