(A and B) Responses of the Tar-only mutant (f1 = 1, dashed line), the Tsr-only mutant (f2 = 1, dot-dashed line), and the WT strain (f1 = f2 = 0.5, solid line) to a series of pH steps with varying step sizes and but same ambient pH level (pH0 = 7.0). (C) Their relative responses (normalized by the maximum response value among all the data points in each subfigure) versus the poststimulation pH, denoted as pH1 = pH0 + ΔpH. (Left panel) Obtained from our model results in panel B and is compared with the experimental measurements (right panel) in Yang and Sourjik (9).