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Integrin α3β1 is required for podocyte adhesion to the glomerular basement membrane. (A) CD151/integrin α3β1 interactions play an important role in determining strong adhesion of podocytes to the GBM, thus protecting the glomerulus from stress-mediated injury. (B) Loss of CD151 or loss and/or mutations of the integrin α3 subunit leads to podocyte detachment and loss and consequent glomerular damage.
