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. 2013 Mar 22;2(3):267–276. doi: 10.1002/cam4.67

Figure 4.

Figure 4

Inhibitory effects of HL-23 on the primary tumor growth of LM8 cells in homograft mouse models in vivo. (a) Weight of subcutaneous primary tumor of the mouse models treated with HL-23 for 14 days. Error bars indicate SE (n = 6 per group).*P < 0.05 to control. (b) Representative micrographs of subcutaneous primary tumor resected from the mouse models treated with HL-23 for 14 days by TUNEL method. Scale bars: 500 μm (×100), 50 μm (×400). Dotted enclosures indicate apoptotic tumor cells. Control: 5% glucose solution, DMPC liposomes: 203 mg/kg/day, HL-23: 203 mg/kg/day for DMPC, 41 mg/kg/day for C12(EO)23. HL, hybrid liposomes; LM8, murine osteosarcoma; SE, standard error; DMPC, l-α-dimyristoylphosphatidylcholine; C12(EO)23, polyoxyethylene(23) dodecyl ether.