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. 2013 Apr 2;2(3):286–295. doi: 10.1002/cam4.76

Figure 2.

Figure 2

Antitumor effects of unencapsulated and liposomal DXR (A–D) and histological analysis after the treatment (E–G). Adrenal tumor size (A and B) and survival time (C and D) after treatment with unencapsulated doxorubicin (DXR) (A and C) or liposomal DXR (B and D). The arrows indicate the times of drug treatment. The tumor size represents the sum of the volumes of the left and right adrenal glands calculated from MR images. Each value represents the mean ± SD (n = 5–6). *P < 0.05, **P < 0.01 versus control mice at 19 weeks of age. (E–G) Histological analysis of the adrenal tumors 1 week after injection of saline (E), unencapsulated DXR (F), or liposomal DXR (G) at 5 mg/kg into 14-week-old transgenic mice. The sections were stained with H&E. N, necrotic area. Scale bar = 500 μm.