Table 1.
EGFR, KRAS, BRAF, HER-2, and ALK mutation status in brain metastases from NSCLC and patient characteristics
| Mutation status in brain metastases | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| No | Sex | Age | EGFR | KRAS | BRAT | HER-2 | ALK | Metastases anatomical location | Smoking status |
| BM1 | F | 70 | wt | G12D | wt | wt | nc | Supratentorial | nc |
| BM2 | M | 40 | wt | G12C | wt | wt | nc | Supratentorial | Current smoker |
| BM3 | M | 60 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM4 | F | 47 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM5 | M | 54 | wt | wt | wt | wt | nc | nc | nc |
| BM6 | F | 50 | wt | G12C | wt | wt | nc | Supratentorial | nc |
| BM7 | M | 66 | wt | wt | wt | wt | nc | Infratentorial | nc |
| BM8 | M | 65 | wt | G12C | wt | wt | nc | Supratentorial | nc |
| BM9 | F | 75 | L858R | wt | wt | wt | nc | Supratentorial | nc |
| BM10 | M | 69 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM11 | F | 57 | wt | G12V | wt | nc | nc | Supratentorial | nc |
| BM12 | M | 80 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM13 | M | 56 | L858R | wt | wt | wt | nc | Supratentorial | Non smoker |
| BM14 | M | 54 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM15 | F | 54 | wt | G12C | wt | wt | nc | Supratentorial | nc |
| BM16 | M | 54 | wt | G12V | wt | wt | nc | Supratentorial | Current smoker |
| BM17 | M | 54 | wt | G12C | wt | wt | nc | nc | Current smoker |
| BM18 | M | 54 | wt | wt | wt | wt | No rearrangement | Supratentorial | nc |
| BM19 | M | 64 | wt | G12V | wt | wt | nc | nc | nc |
| BM20 | M | 67 | L858R | wt | wt | wt | nc | Infratentorial | nc |
| BM21 | M | 57 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM22 | M | 77 | wt | wt | wt | wt | No rearrangement | Supratentorial | Ex-smoker |
| BM23 | M | 66 | wt | G12C | wt | wt | nc | Supratentorial | nc |
| BM24 | M | 55 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM25 | F | 60 | wt | G12V | wt | wt | nc | Supratentorial | nc |
| BM26 | F | 59 | wt | G12D | wt | wt | nc | Supratentorial | Current smoker |
| BM27 | M | 79 | wt | G12V | wt | wt | nc | Supratentorial | Ex-smoker |
| BM28 | M | 57 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM29 | M | 59 | wt | wt | wt | wt | No rearrangement | nc | nc |
| BM30 | M | 61 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM31 | F | 52 | wt | G13D | wt | wt | nc | Supratentorial | nc |
| BM32 | M | 71 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM33 | M | 58 | wt | wt | wt | wt | nc | Infratentorial | Current smoker |
| BM34 | M | 83 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM35 | M | 61 | wt | G12C | wt | wt | nc | Supratentorial | Current smoker |
| BM36 | M | 66 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM37 | F | 54 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM38 | M | 60 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM39 | F | 42 | wt | G12C | wt | wt | nc | Supratentorial | nc |
| BM40 | F | 52 | wt | wt | wt | wt | No rearrangement | Supratentorial | Current smoker |
| BM41 | M | 54 | wt | G12F | wt | wt | nc | Supratentorial | Ex-smoker |
| BM42 | F | 68 | wt | G12A | wt | wt | nc | Supratentorial | Ex-smoker |
| BM43 | M | 52 | wt | G12V | wt | wt | nc | Supratentorial | Non smoker |
| BM44 | M | 52 | wt | G12V | wt | wt | nc | Supratentorial | Current smoker |
| BM45 | M | 52 | wt | G12C | wt | wt | nc | Supratentorial | Current smoker |
| BM46 | F | 58 | wt | G12C | wt | wt | nc | Supratentorial | Ex-smoker |
| BM47 | M | 61 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM48 | M | 67 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM49 | M | 58 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM50 | F | 57 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM51 | F | 65 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM52 | M | 59 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM53 | M | 81 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM54 | M | 70 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM55 | M | 65 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM56 | M | 66 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM57 | F | 49 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM58 | M | 69 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM59 | M | 67 | wt | wt | wt | wt | nc | Infratentorial | Current smoker |
| BM60 | F | 35 | wt | wt | wt | wt | nc | Infratentorial | nc |
| BM61 | M | 58 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM62 | M | 39 | wt | wt | wt | wt | nc | Supratentorial | nc |
| BM63 | F | 48 | wt | wt | wt | wt | nc | Supratentorial | Non smoker |
| BM64 | M | 53 | wt | G13D | wt | wt | nc | Supratentorial | Ex-smoker |
| BM65 | M | 80 | wt | G12V | wt | wt | nc | Supratentorial | Current smoker |
| BM66 | M | 52 | wt | wt | wt | wt | nc | Supratentorial | Ex-smoker |
| BM67 | M | 64 | wt | wt | wt | wt | nc | Supratentorial | Current smoker |
| BM68 | M | 55 | wt | wt | wt | wt | No rearrangement | Supratentorial | Ex-smoker |
| BM69 | F | 45 | wt | G12C | wt | wt | No rearrangement | Supratentorial | Current smoker |
| BM70 | F | 47 | wt | G12V | wt | wt | No rearrangement | Supratentorial | nc |
| BM71 | F | 53 | wt | G12C | wt | wt | No rearrangement | Supratentorial | nc |
| BM72 | F | 47 | wt | G12V | wt | wt | No rearrangement | Supratentorial | nc |
| BM73 | M | 57 | wt | G12A | wt | wt | No rearrangement | Supratentorial | nc |
| BM74 | M | 63 | wt | wt | wt | wt | No rearrangement | Supratentorial | nc |
| BM75 | M | 59 | wt | wt | wt | wt | No rearrangement | Supratentorial | nc |
| BM76 | M | 75 | wt | wt | wt | wt | No rearrangement | Supratentorial | nc |
| BM77 | F | 43 | wt | G12V | wt | wt | No rearrangement | Supratentorial | nc |
BM, brain metastase; wt, wild-type; ADC, adenocarcinoma; SCC, squamous cell carcinoma; LCC, large cell carcinoma; nc, noncommunicated.