Table 1.

Dose escalation scheme and cycle 1 dose limiting toxicity events (DLTs)

Cohort level	ABT-510 (mg, twice daily)	Bevacizumab (mg/kg, every 14 days)	No. of patients	No. of DLTs	DLT events
1	50	5	3	0
2	50	10	3	0
3	100	10	6	1	Grade 2 GI bleed
Expanded cohort	100	10	22	0

GI, gastrointestinal.