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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Cell Biol. 2013 Apr 21;15(6):647–658. doi: 10.1038/ncb2718

Fig. 5. TFEB regulates lipid catabolism through the autophagic pathway.

Fig. 5

a) Mice with indicated genotype were kept on a high-fat diet for 12 weeks when indicated (HFD). Gross liver morphology (upper panel), H/E (middle panel), and oil red O staining of liver sections (bottom panel). b) Bar graph shows normalized liver weights (mean±s.d. for n=10) and c) total lipid content in mice with indicated genotype (mean±s.d. for n=10). *P≤0.05; **P≤0.01; ***P≤0.001 compared to control. d) Toluidin blue staining of liver sections isolated from ATG7KO mice injected with HDAd-ctr or HDAd-TFEB vector. e) Bar graph shows normalized liver weights (mean±s.d. for n=10 ***P≤0.001) and f) total lipid content in mice with indicated genotype (mean±s.d. for n=5; ***P≤0.001). Mice injected with an empty HDAd virus behaved as wild-type untreated mice, therefore data is not represented in the figure.