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Schematic of N-diazeniumdiolate-modified silica nanoparticles as NO delivery scaffolds synthesized via two different routes: (A) post-formation; and, (B) pre-formation strategies. Represented are example syntheses using tetraethoxysilane (TEOS) and N-(6-aminohexyl)aminopropyltrimethoxysilane (AHAP3) as tetraalkoxy- and aminoalkoxysilane precursors, respectively.
