TABLE 1.

Analysis of histopathological changes before and after treatment for each therapeutic group

Variables				Treatments
	G			L+G		L+G+BCG
	Before	After	p	Before	After	p	Before	After	p
	n° (%)	n° (%)	p	n° (%)	n° (%)	n° (%)	n° (%)
Epiderm
Acanthosis	8 (100)	3 (37,5)	0,007	7 (100)	1 (14,3)	0,001	7 (87,5)	1 (12,5)	0,003
Exocytosis	6 (75,0)	0 0,002	5 (71,4)	1 (14,3)	0,031	5 (62,5)	0 0,007
Papillomatosis	8 (100)	3 (37,5)	0,007	7 (100)	2 (28,6)	0,005	6 (75,0)	0	0,002
Hyperkeratosis	7 (87,5)	6 (75,0)	N.s.	7 (100)	4 (57,1)	N.s.	7 (87,5)	6 (75,0)	N.s.
Dyskeratosis	7 (87,5)	1 (12,5)	0,003	5 (71,4)	1 (14,3)	0,003	4 (50,0)	0	0,021
Derm
TFG	2 (25,0)	1(12,5)	N.s.	1 (14,3)	2 (28,6)	N.s.	2 (25,0)	3 (37,5)	N.s.
Granuloma	0	1(12,5)	N.s.	0	0		0	0

G: Glucantime; L+G: Leishvacin+Glucantime; L+G+BCG: Leishvacin+Glucantime+BCG;

TFG: tendency to formation of granuloma; N.s.: Not significant. Chi-square test.